Y-site compatibility for common ICU and med-surg infusions and IV pushes — evidence-graded. A verdict only appears when it is backed by peer-reviewed research, and each one shows its source, its confidence level, and exactly why. If the research doesn't exist, the pair stays a "?" rather than a guess.
⚠ How to read this — and why to still call pharmacy. Y-site compatibility depends on concentration, diluent, contact time, and infusion conditions, so even a cited verdict may not match your exact situation. Confirmed = agreement across 3+ peer-reviewed studies. Limited evidence = only 1–2 studies — treat as a lead, not a guarantee. "?" = no qualifying peer-reviewed study found; it is neither "safe" nor "unsafe," just unestablished. Verdicts are compiled from peer-reviewed literature and FDA labeling; this tool is not affiliated with or reproducing Trissel's, Lexidrug, or Micromedex. For TPN, blood products, lipids, chemotherapy, or any high-alert med, always call pharmacy. This is a nursing education tool, not a substitute for pharmacy consultation or your facility's compatibility table.
✓ Compatible! Caution / variable✗ Incompatible? Data not available
Select two drugs
Pick a drug in each dropdown to see the Y-site compatibility verdict.
View full compatibility matrix
Outlined, bold cells are backed by a peer-reviewed citation (hover for the source). Plain ? cells have no qualifying study yet. This is Batch 1 — coverage grows as more literature is reviewed.
Sources (peer-reviewed literature & FDA labeling)
Every cited verdict above links to one of these. Compatibility findings are facts drawn from the primary literature and FDA labeling — not reproduced from any proprietary database.
Need a printable bedside cheat?
The ICU brain sheet has a built-in lines/drips compatibility column. Build one with your unit's specific drips.
